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scientific evidence

Best age to start incorporating retinol into your routine, according to dermatologists

Experts share the best concentrations, timing, and products for true effectiveness  


Shirley Gomez
Senior Writer
JANUARY 6, 2025 12:17 PM EST

Retinol is one of the active ingredients with the most scientific evidence supporting its effectiveness for the skin. Belén Acero, the owner of the Avenida de América Pharmacy and a specialist in dermopharmacy and nutrition, confirms this. She explains, "It is scientifically proven that retinol acts on both the surface of the skin, known as the epidermis, and deeper in the dermis to combat the signs of skin aging."

Acero has clarified that retinol, a vitamin A derivative, enhances the appearance of fine lines and wrinkles while reducing dark spots due to its depigmenting properties. Furthermore, it stimulates collagen production and has antioxidant effects, which help protect the skin from damage caused by free radicals—primary contributors to premature aging. In addition to these benefits, retinol minimizes pores and improves skin firmness. While it offers numerous advantages, it is essential to be aware of one potential drawback and follow certain precautions.

Assorted glass bottles with cosmetic liquids, serum or gel. Vibrant trendy background of cosmetic products, flat lay style© Getty Images
Assorted glass bottles with cosmetic liquids, serum or gel. Vibrant trendy background of cosmetic products, flat lay style

The Drawbacks of Retinol  

Despite its advantages, retinol can be photosensitizing and irritating. Using it requires care, especially regarding concentration and timing. Experts recommend nighttime application and thorough morning cleansing, particularly for sensitive skin.  

Another key consideration is the adjustment period known as "retinization," during which the skin may experience mild irritation, redness, or peeling. Starting with the right product and gradually building tolerance is crucial for achieving the best results. 

When to Start Using Retinol  

Dr. Marta García-Legaz, a dermatologist at Instituto Médico Ricart, emphasizes, "Retinol can be used from a young age." She notes that its effects are most noticeable in mature skin but can also benefit younger individuals with specific skin concerns, such as acne.  

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Here's how retinol can be effectively used at different life stages.  

In Adolescence

Retinol is primarily recommended for teenagers to address acne scars and dark spots. Formulas combining retinol with glycolic or salicylic acid help control oil production and reduce breakouts. Products with low-concentration retinol, encapsulated retinol (to minimize irritation), or retinal (which has antibacterial properties) are ideal for this age group.  

In Your 20s and 30s  

At this stage, retinol can target two primary concerns:  

  • Dark spots and hyperpigmentation: When paired with consistent sunscreen use, retinol helps fade discoloration, often caused by hormonal changes or birth control.  
  • Preventing fine lines: Experts recommend introducing retinol around age 25 to maintain youthful, smooth skin and delay the signs of aging.  
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In Your 40s and 50s 

Retinol is essential for skincare, boosting collagen production, improving texture and tone, and reducing wrinkles. Products with higher concentrations (0.3%–0.5%) are often recommended to enhance firmness and radiance at this stage.  

For Mature Skin (50+)

Retinol is particularly effective in addressing advanced signs of aging in individuals over 50, such as deeper wrinkles and loss of elasticity. Products designed for deeper, rapid action deliver long-lasting, visible results.  

Who Can Benefit from Retinol?  

Dr. García-Legaz explains that most skin types can benefit from retinol, provided it is introduced gradually and tailored to individual needs. Combination and oily skin types and those with early signs of aging are particularly well-suited to this powerful ingredient.  

Interestingly, individuals with rosacea may also benefit from retinol due to their oily skin, though care must be taken to prevent irritation.  

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Expert Tips and Recommendations  

Dr. Hannah Kopelman, a dermatologist with expertise in hair loss and skin cancer, advises introducing retinol in the late teens for acne, uneven texture, or sun damage. She cautions, "It's not a one-size-fits-all solution. For sensitive or dry skin, I may recommend alternatives like azelaic acid or niacinamide."  

Recommended Products:

  •  SkinCeuticals Retinol 0.3: A potent formula with soothing ingredients.  
  • La Roche-Posay Retinol B3 Serum: Combines retinol with hydrating niacinamide.  
  • Differin Gel: A retinoid ideal for acne-prone skin with minimal irritation.  

According to Dr. Donald B. Yoo, a board-certified facial plastic surgeon, retinol is a cornerstone of anti-aging regimens. "Retinol boosts collagen and accelerates skin cell turnover," he explains. Teens with acne can benefit from prescription retinoids like Retin-A Micro, while medical-grade retinol products (e.g., SkinCeuticals or Skinbetter Science) offer dramatic results for mature skin.  

He advises beginners to apply retinol every third night, gradually increasing the frequency as the skin adjusts. Avoid delicate areas such as the eyes, nose, and lips to minimize irritation.  

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Dr. Viktoryia Kazlosukaya, a board-certified dermatologist and founder of Dermatology Circle, adds, "I would discourage the use of retinol as an anti-aging product at an early age, as it's unnecessary. Early use can cause dryness and disrupt the skin barrier. Usually, retinol can be introduced in your 20s."  

For acne, however, she suggests stronger retinoids (such as Adapalene or Tretinoin) may be safely used from as early as age 9 in some cases. Over-the-counter options like Differin are effective for teens and are backed by extensive safety data.  

How do you incorporate retinol into your beauty routine?

If you're a beginner using retinol, don't worry about potential skin irritation as long as you properly introduce it into your skincare routine. Your skin must undergo a retinization process to adjust to this active ingredient, typically lasting four to six weeks. During this time, you may experience dryness, irritation, redness, and even peeling. That's why it's essential to gradually incorporate retinol into your routine to minimize these side effects. Start with low concentrations, apply it at night on a clean, dry face, and follow these recommendations from pharmacist Belén Acero.

rename skincare© GettyImages
Retinol is one of those ingredients that are like a toxic relationship. Sure, it helps to improve skin texture, reduce fine lines and wrinkles, and even out hyperpigmentation, but it also has what can only be described as a scorched earth aftermath redness, irritation, peeling, and sensitivity.
  1. Sun protection must be applied daily and reapplied every two hours. Choose a high SPF, preferably 50 or higher, to minimize adverse reactions. 
  2. To enhance skin hydration and protection, opt for facial creams that contain active ingredients with barrier functions, such as ceramides, niacinamide, or hyaluronic acid, with various molecular weights. 
  3. Avoid combining retinol with other irritating ingredients, such as alpha hydroxy acids (such as glycolic, azelaic, citric, or mandelic acid) and salicylic acid. 
  4. If you stop using retinol and later decide to reintroduce it, you'll need to go through the same process of gradually acclimating your skin to it once again. 
  5. To help your skin better tolerate retinol, it's recommended to use facial masks rich in moisturizing, repairing, and soothing ingredients, such as aloe vera, cucumber extract, or Centella Asiatica. Remember, masks typically contain a higher concentration of active ingredients. 

When appropriately used, retinol offers numerous scientifically backed benefits, which is why it has become one of the most sought-after ingredients in skincare. 

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